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In the mortal diseases, lung cancer, approximately one fifth of lung adenocarcinoma(LUAD) patients are associated with brain metastasis(BM). And even some patients die of BM. In the present research, the 22753 genes data of 273 primary LUAD or BM samples were downloaded from gene expression omnibus(GEO) datasets. The 145 common differentially expressed genes(DEGs) both from GPL96 and GPL570 platform profiles were screened out by R package. Gene ontology(GO), pathway and protein protein interaction(PPI) network analysis of the DEGs was enriched by online tools. The 14 up- and 131 down-regulated genes were enriched in 18 GO terms and 147 signal pathway. Protein expression of AGRP and ESPL1 is lower in lung cancer than many other cancers. And the km-plots of lung cancer survival curves are also shown that AGRP and ESPL1 express higher in high risk groups. From the research in this paper, we can believe that AGRP and ESPL1 might be the biomarkers for the diagnostic clue of BM from LUAD.

AGRP and ESPL1 as Biomarkers of Brain-Metastasis in Lung Adenocarcinoma