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Diabetes nephropathy (DN) is characterized by gathering of extracellular matrix (ECM) in the kidney. Extracellular matrix (ECM) degradation could influence by high glucose concentration through the activities of MMPs. ECM gathering is engaged in the pathogenesis of diabetic nephropathy. Matrix metalloproteinases (MMPs) are types of enzymes, which are mostly parted in ECM homeostasis. In normal kidneys, Gelatinase A (MMP-2) are the most important MMPs, so they may be studied as earlier and more specific markers for DN. This study aimed to evaluate the diagnostic value of MMP-2 as new indicators in diabetic patients. The study included 20 normal people as a control group and 67 samples collected from Al-Faihaa center for diabetes. Lipids profile were measured and MMP-2 levels detected by ELISA technique. The results showed cholesterol levels were at normal rates in control group, and at low risk levels in diabetes groups. Also the low risk levels of triglycerides were detected in diabetes groups, Furthermore, the risk values of HDLCholesterol was detected in group 2 significant increase in the MMp-2 concentration in patients with age 30 years or older which could be as an early sign of diabetes disease.

Alteration on MMP-2 Levels in Women Diabetes Patients in Basrah