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Hepatocellular carcinoma (HCC) is a liver cancer caused by uncontrolled growth of hepatocytes. Many factors relate to the incidence of hepatocellular carcinoma whether it is internal or external factors. This study aimed to determine the risk factors of HCC South Region of Central Java, Indonesia. The study design used a case-control approach using the population of HCC patients from Margono Soekarjo Banyumas Hospital as a referring hospital in a Southern part of Central Java. Samples were considered as total sampling criteria using patient’s database from the hospital. Statistical analysis was Chi-square and Fisher test. The study found that the age and hepatitis B infection have an association with the prevalence of HCC. Individuals infected with hepatitis B were at higher risk of HCC, compared with individuals not infected with hepatitis B. Younger age was a protective factor against HCC. As a conclusion, there was a significant relationship between age and hepatitis B infection with HCC.

Hepatitis B as hepatocellular carcinoma (HCC) risk factor in the south region of Java, Indonesia