English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Particle transport in complex environments such as the interior of livingcells is often (transiently) non-Fickian or anomalous, that is, it deviatesfrom the laws of Brownian motion. Such anomalies may be the result ofsmall-scale spatio-temporal heterogeneities in, or viscoelastic properties of,the medium, molecular crowding, etc. Often the observed dynamics displaysmulti-state characteristics, i.e. distinct modes of transport dynamicallyinterconverting between each other in a stochastic manner. Reliablydistinguishing between single- and multi-state dynamics is challenging andrequires a combination of distinct approaches. To complement the existingmethods relying on the analysis of the particle's mean squared displacement,position- or displacement-autocorrelation function, and propagators, we herefocus on "scattering fingerprints" of multi-state dynamics. We develop atheoretical framework for two-state scattering signatures -- the intermediatescattering function and dynamic structure factor -- and apply it to theanalysis of simple model systems as well as particle-tracking experiments inliving cells. We consider inert tracer-particle motion as well as systems withan internal structure and dynamics. Our results may generally be relevant forthe interpretation of state-of-the-art differential dynamic microscopyexperiments on complex particulate systems, as well as inelastic orquasielastic neutron (incl. spin-echo) and X-ray scattering scattering probingstructural and dynamical properties of macromolecules, when the underlyingdynamics displays two-state transport.

Scattering fingerprints of two-state dynamics