Open AccessImmune-mediated vincristine-induced neuropathy: Unlocking therapies
Author(s) -
Masha G. Savelieff,
Eva L. Feldman
Publication year - 2021
Publication title -
the journal of experimental medicine/the journal of experimental medicine
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 8.483
H-Index - 448
eISSN - 1540-9538
pISSN - 0022-1007
DOI - 10.1084/jem.20210286
Subject(s) - vincristine , immune system , peripheral neuropathy , medicine , innate immune system , immunology , immunotherapy , cancer , complication , chemotherapy , cyclophosphamide , diabetes mellitus , endocrinology
Vincristine-induced peripheral neuropathy (VIPN) is a prevalent and painful complication in cancer patients that lacks effective treatments. In this issue of JEM, Starobova et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20201452) report that VIPN is driven by innate immune system activation, a discovery that unlocks immunotherapies as potential treatments.