Open AccessAnalyzing signaling activity and function in hematopoietic cells
Author(s) -
Tobías Kull,
Timm Schroeder
Publication year - 2021
Publication title -
the journal of experimental medicine/the journal of experimental medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.483
H-Index - 448
eISSN - 1540-9538
pISSN - 0022-1007
DOI - 10.1084/jem.20201546
Subject(s) - haematopoiesis , context (archaeology) , signal transduction , progenitor cell , biology , stem cell , function (biology) , cell signaling , microbiology and biotechnology , relevance (law) , computational biology , neuroscience , law , paleontology , political science
Cells constantly sense their environment, allowing the adaption of cell behavior to changing needs. Fine-tuned responses to complex inputs are computed by signaling pathways, which are wired in complex connected networks. Their activity is highly context-dependent, dynamic, and heterogeneous even between closely related individual cells. Despite lots of progress, our understanding of the precise implementation, relevance, and possible manipulation of cellular signaling in health and disease therefore remains limited. Here, we discuss the requirements, potential, and limitations of the different current technologies for the analysis of hematopoietic stem and progenitor cell signaling and its effect on cell fates.