Open AccessUnfolding innate mechanisms in the cancer microenvironment: The emerging role of the mesenchyme
Author(s) -
Vasiliki Koliaraki,
Ana Henriques,
Alejandro Prados,
George Kollias
Publication year - 2020
Publication title -
the journal of experimental medicine/the journal of experimental medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.483
H-Index - 448
eISSN - 1540-9538
pISSN - 0022-1007
DOI - 10.1084/jem.20190457
Subject(s) - innate immune system , mesenchyme , biology , tumor microenvironment , innate lymphoid cell , cancer , immunology , microbiology and biotechnology , mesenchymal stem cell , immune system , genetics
Innate mechanisms in the tumor stroma play a crucial role both in the initial rejection of tumors and in cancer promotion. Here, we provide a concise overview of the innate system in cancer and recent advances in the field, including the activation and functions of innate immune cells and the emerging innate properties and modulatory roles of the fibroblastic mesenchyme. Novel insights into the diverse identities and functions of the innate immune and mesenchymal cells in the microenvironment of tumors should lead to improved anticancer therapies.