Open AccessThink globally, act locally: Centrosome-localized mRNAs ensure mitotic fidelity
Author(s) -
Daniela C. Zarnescu
Publication year - 2020
Publication title -
the journal of cell biology/the journal of cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.414
H-Index - 380
eISSN - 1540-8140
pISSN - 0021-9525
DOI - 10.1083/jcb.202010172
Subject(s) - centrosome , biology , mitosis , microbiology and biotechnology , regulator , messenger rna , genetics , cell , gene , cell cycle
The functional importance of mRNA localization to centrosomes is unclear. Ryder et al. (2020. J. Cell Biol. https://doi.org/10.1083/jcb.202004101) identify fragile-X mental retardation protein as a regulator of centrocortin (cen) mRNA dynamics in Drosophila. Mistargeting of cen impairs division and development, indicating that cen mRNA localization to centrosomes ensures mitotic fidelity.