Open AccessEndophilin A1 drives acute structural plasticity of dendritic spines in response to Ca2+/calmodulin
Author(s) -
Yanrui Yang,
Chen Jiang,
Xue Chen,
Di Li,
Jianfeng He,
Shen Wang,
Suping Zhao,
Xiaoyu Yang,
Shikun Deng,
Chunfang Tong,
Dou Wang,
Zhenzhen Guo,
Dong Liu,
Cong Ma,
Xin Liang,
Yun Stone Shi,
Jiajia Li
Publication year - 2021
Publication title -
the journal of cell biology/the journal of cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.414
H-Index - 380
eISSN - 1540-8140
pISSN - 0021-9525
DOI - 10.1083/jcb.202007172
Subject(s) - long term potentiation , dendritic spine , biology , ltp induction , microbiology and biotechnology , calmodulin , synaptic plasticity , actin cytoskeleton , actin , actin remodeling of neurons , cytoskeleton , dendritic filopodia , neuroscience , excitatory postsynaptic potential , synapse , receptor , cell , biochemistry , inhibitory postsynaptic potential , hippocampal formation , enzyme
Induction of long-term potentiation (LTP) in excitatory neurons triggers a large transient increase in the volume of dendritic spines followed by decays to sustained size expansion, a process termed structural LTP (sLTP) that contributes to the cellular basis of learning and memory. Although mechanisms regulating the early and sustained phases of sLTP have been studied intensively, how the acute spine enlargement immediately after LTP stimulation is achieved remains elusive. Here, we report that endophilin A1 orchestrates membrane dynamics with actin polymerization to initiate spine enlargement in NMDAR-mediated LTP. Upon LTP induction, Ca2+/calmodulin enhances binding of endophilin A1 to both membrane and p140Cap, a cytoskeletal regulator. Consequently, endophilin A1 rapidly localizes to the plasma membrane and recruits p140Cap to promote local actin polymerization, leading to spine head expansion. Moreover, its molecular functions in activity-induced rapid spine growth are required for LTP and long-term memory. Thus, endophilin A1 serves as a calmodulin effector to drive acute structural plasticity necessary for learning and memory.