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Effect of cyclic polylactates on tumor cells and tumor bearing mice
Author(s) -
Takada Shigeo,
Nagato Yasukazu,
Yamamura Masaichi
Publication year - 1997
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549700203761
Subject(s) - lactic dehydrogenase , pyruvate kinase , lactate dehydrogenase , glycolysis , ascites , tumor cells , pkm2 , lactic acid , anaerobic exercise , anaerobic glycolysis , chemistry , metabolism , cancer research , biochemistry , biology , enzyme , medicine , bacteria , physiology , genetics
We studied the effect of cyclic polylactates ranging in size from a degree of polymerization number of 3 to 13 on pyruvate kinase, lactic dehydrogenase, anaerobic glycolysis, growth of tumor cells and survival of tumor bearing mice. Pyruvate kinase and lactic dehydrogenase activities were both inhibited by cyclic polylactates, and the inhibition mechanism of cyclic polylactates on lactic dehydrogenase was noncompetitive. About half the anaerobic glycolytic activity of FM3A ascites tumor cells was inhibited and tumor cell growth was also effectively inhibited by cyclic polylactates. Mice, which were treated with cyclic polylactates after inoculation of FM3A ascites tumor cells lived significantly longer than mice, which were treated with vehicle or non mice.