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Catalase and the production of brain acetaldehyde: a possible mediator of the psychopharmacological effects of ethanol
Author(s) -
SMITH BRIAN R.,
ARAGON CARLOS M. G.,
AMIT ZALMAN
Publication year - 1997
Publication title -
addiction biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 78
eISSN - 1369-1600
pISSN - 1355-6215
DOI - 10.1080/13556219772570
Subject(s) - acetaldehyde , catalase , ethanol , mediation , mediator , psychology , chemistry , enzyme , biochemistry , medicine , endocrinology , political science , law
This review represents an attempt to assess the available data on the role of catalase in the mediation of the behavioral actions of ethanol and the regulation of voluntary ethanol consumption. It is argued that acetaldehyde may be formed in brain through the peroxidatic activity of catalase. Furthermore, acetaldehyde formed centrally through the activity of this enzyme, may be responsible, at least in part, for some of the motivational, behavioral and neurotoxic effects of ethanol.