Open AccessKimura's Disease Associated with Ulcerative Colitis: Detection of IL-5 mRNA Expression of Peripheral Blood Mononuclear Cells and Colon Lesion
Author(s) -
Makoto Sugaya
Publication year - 1998
Publication title -
acta dermato venereologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.982
H-Index - 83
eISSN - 1651-2057
pISSN - 0001-5555
DOI - 10.1080/000155598443105
Subject(s) - ulcerative colitis , peripheral blood mononuclear cell , eosinophilia , medicine , lesion , reverse transcriptase , inflammatory bowel disease , immunology , immunoglobulin e , pathology , disease , polymerase chain reaction , antibody , biology , in vitro , gene , biochemistry
Kimura's disease is considered to be a Th2 type allergic reaction based on the presence of eosinophilia and IgE hyperimmunoglobulinemia. We report a 26-year-old Japanese male with this disorder associated with ulcerative colitis. IL-5 is a selective stimulator for the production of eosinophilia and is considered to play an important role in Kimura's disease. IL-5 mRNA from peripheral blood mononuclear cells and the colon lesion were detected by the reverse-transcriptase polymerase chain reaction method, indicating that IL-5 can also be of importance in ulcerative colitis.
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