open-access-imgOpen AccessTissue-specific expression of an unusual H-2 (class I)-related gene.
David Cosman,
Michel Kress,
George Khoury,
Gilbert Jay
Publication year1982
Publication title
proceedings of the national academy of sciences of the united states of america
Resource typeJournals
Sequence analysis of mouse H-2 cDNA clones has suggested the existence of an unusual class of H-2 (class I)-related antigens that, unlike the classical membrane-associated molecules, retains only the extracellular portion and is likely to be secreted. The expression of this class of H-2-related mRNA is tissue restricted; it is detectable in liver but not in brain, kidney, testis, thymus, or spleen. In the liver, its accumulation represents about one-fourth of all the H-2 (class I)-specific transcripts. This class of transcripts is present in mice of different inbred strains, but the level of expression differs markedly among them. A model is presented in which such a soluble form of the H-2 antigen would play the role of a blocking factor in maintaining peripheral inhibition of H-2 recognition. This would ensure tolerance of the H-2 molecule as a self antigen while permitting it to act as a guidance molecule for the associative recognition of viral and tumor antigens by cytotoxic T cells.
Subject(s)antigen , biology , complementary dna , cytotoxic t cell , gene , gene expression , genetics , immunology , in vitro , messenger rna , microbiology and biotechnology , spleen
SCImago Journal Rank5.011

Seeing content that should not be on Zendy? Contact us.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here