English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

In order to target threatening pathogens, the adaptive immune system performsa continuous reorganization of its lymphocyte repertoire. Following an immunechallenge, the B cell repertoire can evolve cells of increased specificity forthe encountered strain. This process of affinity maturation generates a memorypool whose diversity and size remain difficult to predict. We assume that theimmune system follows a strategy that maximizes the long-term immune coverageand minimizes the short-term metabolic costs associated with affinitymaturation. This strategy is defined as an optimal decision process on a finitedimensional phenotypic space, where a pre-existing population of naive cells issequentially challenged with a neutrally evolving strain. We unveil a trade-offbetween immune protection against future strains and the necessaryreorganization of the repertoire. This plasticity of the repertoire drives theemergence of distinct regimes for the size and diversity of the memory pool,depending on the density of naive cells and on the mutation rate of the strain.The model predicts power-law distributions of clonotype sizes observed in data,and rationalizes antigenic imprinting as a strategy to minimize metabolic costswhile keeping good immune protection against future strains.

Affinity maturation for an optimal balance between long-term immune coverage and short-term resource constraints