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Significance The University of Maryland Global COVID Trends and Impact Survey (UMD-CTIS), launched April 2020, is the largest remote global health monitoring system. This study includes ∼30 million responses through December 2020 from all 114 countries/territories with survey weights to adjust for nonresponse and demographics. Using self-reported cross-sectional survey data sampled daily from Facebook users, we confirm consistent demographics and COVID-19 symptoms. Our global model predicts local COVID-19 case trends. Importantly, one survey item strongly correlates with reported cases, demonstrating potential utility in locales with scant UMD-CTIS sampling or government data. Despite limitations resulting from sampling, nonresponse, coverage, and measurement error, UMD-CTIS has the potential to support existing monitoring systems for COVID-19 as well as other new as-yet-undefined global health threats.

Global monitoring of the impact of the COVID-19 pandemic through online surveys sampled from the Facebook user base