Open AccessTransfer transcriptomic signatures for infectious diseases
Author(s) -
Julia di Iulio,
István Bartha,
Roberto Spreafico,
Herbert W. Virgin,
Amalio Telenti
Publication year - 2021
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2022486118
Subject(s) - transcriptome , identification (biology) , biology , tuberculosis , computational biology , human pathogen , gene , virology , genetics , medicine , gene expression , ecology , pathology
Significance Human responses to infection include transcriptional changes shared across diverse pathogens. To capture these common patterns, we establish the concept of, and the method for, the identification of “transfer signatures”: sets of genes defining human immunophenotypes. We demonstrate the usefulness of transfer signatures in two use cases: the progression of latent to active tuberculosis and the severity of viral respiratory infections.