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Significance Immunoglobulin heavy chain checkpoint (IgHCC) is a critical step during early B cell development. The role of immunoglobulin heavy chain (IgHC) at this step is well established. However, with the expanding knowledge of RNA in regulating central biological processes, there could be a noncoding contribution of IgHC mRNA (IgHR ) in controlling the IgHCC. Here, we generated a novel mouse model that enabled us to determine a potential role ofIgHR in the IgHCC, independent of IgHC signaling. Our data indicate thatIgHR has no role in IgHCC and the latter is predominantly controlled by IgHC, as proposed earlier. Furthermore, this study highlights the sensitivity of progenitor B cells to low amounts of IgHC.

The Ig heavy chain protein but not its message controls early B cell development