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Significance Microorganisms can be rationally engineered to convert CO2 and H2 O into chemicals, replacing those made from fossil fuels today. Sometimes such chemicals are poorly soluble in water or negatively affect the growth of the microorganism, resulting in cost-inefficient manufacturing. In nature, this problem is often solved by converting incompatible chemicals into those more compatible with the host and/or environment. Inspired by this, we propose a similar strategy for engineered biotechnology, whereby biochemical conversion inside the microorganism is followed by chemical reversal once outside. The principle was demonstrated with 1-octanol by implementing two different conversion methods in two different species, showing enhanced bioproduction in most cases. The approach may stimulate commercialization of sustainable and renewable production of chemicals.

Bioderivatization as a concept for renewable production of chemicals that are toxic or poorly soluble in the liquid phase