Open AccessThe antimicrobial peptide ZY4 combats multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii infection
Author(s) -
James Mwangi,
Yizhu Yin,
Wang Gan,
Min Yang,
Yongdong Wang,
Zhiye Zhang,
Ren Lai
Publication year - 2019
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.1909585117
Subject(s) - acinetobacter baumannii , pseudomonas aeruginosa , microbiology and biotechnology , antimicrobial , multiple drug resistance , cathelicidin , antimicrobial peptides , biology , biofilm , antibiotics , peptide , tobramycin , antibiotic resistance , bacteria , biochemistry , genetics
Significance This work showed that a designed cyclic peptide ZY4 exhibits excellent activity againstPseudomonas aeruginosa andAcinetobacter baumannii . ZY4 not only inhibits planktonic growth and biofilm formation but also kills persister cells by permeabilizing bacterial membrane. ZY4 showed low propensity to induce resistance, high stability in vivo, and therapeutic potentials in MDRP. aeruginosa – andA. baumannii –induced infection. The present study provides a promising drug candidate in the war against multidrug resistance.