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Women who have infertility due to anovulation in association with the polycystic ovary syndrome are particularly difficult to treat. A substantial proportion have no response to the induction of ovulation, and those who do have a response are at increased risk for the ovarian hyperstimulation syndrome. This syndrome is characterized by massive ovarian enlargement, ascites, pleural effusion, oliguria, hydrothorax, hemoconcentration, electrolyte disturbances, and in the most severe cases, thromboembolic phenomena related to coagulation disturbances. A woman with the polycystic ovary syndrome who became pregnant after in vitro maturation of oocytes and in vitro fertilization was described in 1994.1  Subsequently, very few pregnancies have been reported in such women, largely because the maturation and fertilization rates of these immature oocytes have been low.2  We report the results of 25 cycles of in vitro fertilization in 20 women with the polycystic ovary syndrome. There was in vitro maturation of immature oocytes retrieved from all 20 women after priming with human chorionic gonadotropin

Priming with Human Chorionic Gonadotropin before Retrieval of Immature Oocytes in Women with Infertility Due to the Polycystic Ovary Syndrome