Open AccessResistance to Parvovirus B19 Infection Due to Lack of Virus Receptor (Erythrocyte P Antigen)
Author(s) -
Kevin Brown,
Jonathan R. Hibbs,
Giorgio Gallinella,
Stacie M. Anderson,
E. Dale Lehman,
Peggy McCarthy,
Neal S. Young
Publication year - 1994
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejm199404283301704
Subject(s) - erythema infectiosum , parvovirus , parvoviridae , medicine , immunology , receptor , phenotype , antigen , virus , virology , biology , genetics , gene
The presence of a specific cellular receptor is thought to be necessary for susceptibility to viral infection. The erythrocyte P antigen is the cellular receptor for parvovirus B19. We hypothesized that the rare persons with the p phenotype, whose erythrocytes do not have this receptor, would be naturally resistant to B19 infection, which causes erythema infectiosum.
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