Open AccessDrug delivery and anticancer activity of biosynthesised mesoporous Fe 2 O 3 nanoparticles
Author(s) -
Abolhasani Zadeh Firoozeh,
Abdalkareem Jasim Saade,
Atakhanova Nigora E.,
Majdi Hasan Sh.,
Abed Jawad Mohammed,
Khudair Hasan Mohammed,
Borhani Fariba,
Khatami Mehrdad
Publication year - 2022
Publication title -
iet nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.366
H-Index - 38
eISSN - 1751-875X
pISSN - 1751-8741
DOI - 10.1049/nbt2.12080
Subject(s) - mesoporous material , nanoparticle , magnetic nanoparticles , drug delivery , nanotechnology , materials science , mesoporous silica , high resolution transmission electron microscopy , chitosan , nuclear chemistry , chemical engineering , drug carrier , chemistry , organic chemistry , transmission electron microscopy , catalysis , engineering
Mesoporous magnetic nanoparticles of haematite were synthesised using plant extracts according to bioethics principles. The structural, physical and chemical properties of mesoporous Fe 2 O 3 nanoparticles synthesised with the green chemistry approach were evaluated by XRD, SEM, EDAX, BET, VSM and HRTEM analysis. Then, their toxicity against normal HUVECs and MCF7 cancer cells was evaluated by MTT assay for 48 h. These biogenic mesoporous magnetic nanoparticles have over 71% of doxorubicin loading efficiency, resulting in a 50% reduction of cancer cells at a 0.5 μg.ml −1 concentration. Therefore, it is suggested that mesoporous magnetic nanoparticles be used as a multifunctional agent in medicine (therapeutic‐diagnostic). The produced mesoporous magnetic nanoparticles with its inherent structural properties such as polygonal structure (increasing surface area to particle volume) and porosity with large pore volume became a suitable substrate for loading the anti‐cancer drug doxorubicin.