Open AccessNephroprotective role of nanoencapsulated Tinospora cordifolia (Willd.) using polylactic acid nanoparticles in streptozotocin‐induced diabetic nephropathy rats
Author(s) -
Ambalavanan Ragavee,
John Arul Daniel,
Selvaraj Asha Devi
Publication year - 2021
Publication title -
iet nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.366
H-Index - 38
eISSN - 1751-875X
pISSN - 1751-8741
DOI - 10.1049/nbt2.12030
Subject(s) - streptozotocin , diabetic nephropathy , nanomedicine , pharmacology , nephropathy , diabetes mellitus , tinospora cordifolia , polylactic acid , chemistry , nanoparticle , medicine , traditional medicine , materials science , endocrinology , nanotechnology , polymer , organic chemistry
Currently, the field of nanomedicine, which uses active compounds from medicinal plants, has emerged as a therapy for diabetic nephropathy. From this study, the renoprotective effect of TC‐loaded PLA Nanoparticles (TC‐PLA NPs) on streptozotocin (STZ)‐induced diabetic nephropathy rats was investigated. The results showed that the nephroprotective effect of TC‐PLA NPs reduces the blood glucose level, regulates the renal parameters, decreases the cytokine levels and reduces the mRNA expressions level of different genes related to diabetic nephropathy.