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JAHK: a low frequency antigen associated with the r G complex of the Rh blood group system
Author(s) -
Green C.,
Coghlan G.,
Bizot M.,
Kasulke D.,
BombailGirard M.,
Wallace M.,
LomasFrancis C.,
Daniels G.
Publication year - 2002
Publication title -
transfusion medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.471
H-Index - 59
eISSN - 1365-3148
pISSN - 0958-7578
DOI - 10.1046/j.1365-3148.2002.00348.x
Subject(s) - blood group antigens , antigen , medicine , group (periodic table) , immunology , physics , quantum mechanics
Summary We have investigated a ‘new’ low frequency antigen JAHK, which is a marker for the rare Rh gene complex r G . The r G haplotype does not produce any D, c or E antigens, but does produce a strong G antigen. The r G haplotype [ d(C)(e)G ] is associated with weak C and weak e antigens. Three unrelated r G /dce individuals and one r G /r G propositus were JAHK+. In addition, three propositi whose red cells had a typical expression of C and/or e antigen, which could not be shown to be r G because of a normal D antigen produced by the haplotype in trans, were also JAHK+. Families of three of the propositi demonstrate the inheritance of JAHK as a Mendelian dominant character. It is likely that the JAHK antigen results from conformational changes in an RhCcEe protein that has the amino acid characteristic of c antigen at position 16 and the amino acid residues characteristic of C antigen at positions 60, 68, and 103. JAHK has been assigned the number RH53.