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Neutralization Titres and Vertical HIV‐1 Transmission
Author(s) -
Bongertz V.,
Costa C. I.,
Veloso V. G.,
Grinsztejn B.,
Filho E. C. J.,
Calvet G.,
Pilotto J. H.
Publication year - 2002
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.2002.01174.x
Subject(s) - neutralization , virology , human immunodeficiency virus (hiv) , transmission (telecommunications) , antibody , biology , virus , immunology , medicine , electrical engineering , engineering
Replication of the human immunodeficiency virus type 1 (HIV‐1) isolate MN in CEM cells was less neutralized by the plasma from the mothers of infected children (MIC) in comparison with the plasma from the mothers of uninfected children (MUC). Significantly higher neutralization titres were observed for the sera from MUCs compared with MICs, and only the sera from MUC showed 100% neutralization of the HIV‐1 MN strain. We suggest that a simple neutralization assay as described here could be useful in prognostic analyses.