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Serum ImmunoglobulinD in Infants and Children
Author(s) -
Ásgeir Haraldsson,
C.M.R. Weemaes,
Soffía Jonasdottir,
Ö Ólafsson,
G.A.S. van de Wiel,
J Goertz,
I.S. Klasen
Publication year - 2000
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.2000.00702.x
Subject(s) - immunoglobulin d , medicine , antibody , icelandic , age groups , immunology , physiology , pediatrics , demography , b cell , linguistics , philosophy , sociology
Serum immunoglobulinD (IgD) concentration is usually low in healthy individuals as compared to other immunoglobulin classes. Most studies on serum IgD are concerned with serum levels in healthy adults but reference values for young children and infants are not easily available. In order to establish age specific reference values we measured IgD levels in serum of 184 healthy Icelandic children, age 0–14 years and 60 healthy blood donors age 18–63, using the ELISA technique. Special attention was paid to the youngest age groups. Results showed low IgD values in infants and young children, gradually increasing until the age of 10 but then decreasing with age. We conclude that IgD gradually increases with age in childhood as other immunoglobulin classes but later declines. These findings can be of importance in revealing the function of IgD in the immune system as well as in the diagnosis of the hyper‐IgD syndrome.