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Vasopressin Regulation of Noradrenaline Release Within the Supraoptic Nucleus
Author(s) -
Ludwig M.,
Onaka T.,
Yagi K.
Publication year - 2000
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1046/j.1365-2826.2000.00516.x
Subject(s) - supraoptic nucleus , microdialysis , vasopressin , medicine , endocrinology , hypothalamus , nucleus , chemistry , oxytocin , neuropeptide , stimulation , neuroscience , receptor , biology , central nervous system
The effect of electrically evoked dendritic vasopressin release on noradrenaline release into the hypothalamic supraoptic nucleus was assessed by in vivo microdialysis in conjunction with high pressure liquid chromatography and electrochemical detection. Electrical activation of magnocellular supraoptic neurones by stimulation of their axons at the level of the neural lobe significantly increased noradrenaline release into the nucleus (2.5‐fold, P<0.03). This increase was completely blocked by administration of a nonpeptide vasopressin V 1a receptor antagonist via the microdialysis probe. These data suggest that dendritically released vasopressin facilitates noradrenaline release into the hypothalamic nucleus.