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Danazol therapy in factor X deficiency
Author(s) -
Mukhopadhyay S.,
Saxena R.,
Kashyap R.,
Choudhry V. P.
Publication year - 2001
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1046/j.1365-2516.2001.00541.x
Subject(s) - danazol , medicine , fresh frozen plasma , prothrombin complex , prothrombin complex concentrate , thrombosis , coagulation , surgery , coagulation disorder , factor x , gastroenterology , endometriosis , warfarin , platelet , thrombin , atrial fibrillation
Factor X (FX) deficiency is a rare coagulation disorder that usually presents with bleeding manifestations and is treated with fresh frozen plasma or prothrombin complex concentrates. We report a case of FX deficiency in which the patient presented with bleeding as well as thrombosis. The patient responded to Danazol and relapsed when the drug was stopped. The occurrence of thrombosis in FX deficiency and the role of Danazol in coagulopathies are reviewed.