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An unusual presentation of diffuse granuloma annulare in an HIV‐positive patient – immunohistochemical evidence of predominant CD8 lymphocytes
Author(s) -
Morris S. D.,
Cerio R.,
Paige D. G.
Publication year - 2002
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1046/j.1365-2230.2002.01008.x
Subject(s) - granuloma annulare , medicine , histology , pathology , immunohistochemistry , dermatology , human immunodeficiency virus (hiv) , presentation (obstetrics) , granuloma , immunology , surgery
Summary Over the past decade there have been several reports in the literature of atypical forms of granuloma annulare (GA) occurring in HIV positive patients. We now report a case of diffuse granuloma annulare in an HIV positive patient with unusual clinical and immunohistological features. Our patient presented with a persistent extensive macular erythematous eruption on his face and upper trunk with bizarre sparing around the nipples and axillae. The histology showed an interstitial pattern of GA, with a predominance of CD8 positive cells, in contrast to the usual CD4 positive infiltrate typically seen in GA.