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A phosphorylated peptide, named K40H, derived from the constant region of IgMs was detected in human serum by liquid chromatography coupled to high-resolution mass spectrometry. Synthetic K40H proved to exert a potent  in vitro  activity against fungal pathogens, and to inhibit HIV-1 replication  in vitro  and  ex vivo . It also showed a therapeutic effect against an experimental infection by  Candida albicans  in the invertebrate model  Galleria mellonella . K40H represents the proof of concept of the innate role that naturally occurring antibody fragments may exert against infectious agents, shedding a new light upon the posthumous role of antibodies and opening a new scenario on the multifaceted functionality of humoral immunity.

A Naturally Occurring Antibody Fragment Neutralizes Infectivity of Diverse Infectious Agents