Open AccessPannexin 3 deletion reduces fat accumulation and inflammation in a sex-specific manner
Author(s) -
Brent Wakefield,
Vanessa R. Lee,
Danielle Johnston,
Parastoo Boroumand,
Nicolas J. Pillon,
Samar Sayedyahossein,
Brooke L. O’Donnell,
Justin Tang,
Rafael E. SanchezPupo,
Kevin Barr,
Robert Gros,
Lauren E. Flynn,
Nica M. Borradaile,
Amira Klip,
Frank Beier,
Silvia Peñuela
Publication year - 2021
Publication title -
international journal of obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.663
H-Index - 225
eISSN - 1476-5497
pISSN - 0307-0565
DOI - 10.1038/s41366-021-01037-4
Subject(s) - endocrinology , medicine , adipose tissue , inflammation , context (archaeology) , white adipose tissue , biology , paleontology
Pannexin 3 (PANX3) is a channel-forming glycoprotein that enables nutrient-induced inflammation in vitro, and genetic linkage data suggest that it regulates body mass index. Here, we characterized inflammatory and metabolic parameters in global Panx3 knockout (KO) mice in the context of forced treadmill running (FEX) and high-fat diet (HFD).
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