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CD4 + T cells from MHC II‐dependent thymocyte–thymocyte interaction provide efficient help for B cells
Author(s) -
Kim Eun Ji,
Choi Bomi,
Moon Hana,
Lee You Jeong,
Jeon Yoon Kyeong,
Park Seong Hoe,
Kim Tae Jin,
Jung Kyeong Cheon
Publication year - 2011
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2011.8
Subject(s) - thymocyte , t cell , biology , negative selection , double negative , major histocompatibility complex , mhc class ii , microbiology and biotechnology , population , cytotoxic t cell , cd8 , antigen presenting cell , immunology , antigen , immune system , in vitro , genetics , medicine , gene , environmental health , genome
Recently, a novel CD4 + T‐cell developmental pathway was reported that generates thymocyte–thymocyte (T–T) CD4 + T cells. We established a mouse system (CIITA tg CIITApIV −/− ) where thymic positive selection occurred only by major histocompatibility complex (MHC) class II + thymocytes. T–T CD4 + T cells selected via MHC class II‐dependent T–T interaction are comprised of PLZF‐negative and innate PLZF‐positive populations. Until recently, the functional role of the PLZF‐negative population was unclear. In this study, we demonstrate that naïve T–T CD4 + T cells provide B‐cell help to a level comparable with that of naïve conventional CD4 + T cells. Considering the absence of PLZF expression in naïve T–T CD4 + T cells, these results suggest that PLZF‐negative naïve T–T CD4 + T cells are functionally equivalent to conventional naïve CD4 + T cells in terms of B‐cell help.