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Independent localization of MAP2 , CaMKIIα and β‐actin RNAs in low copy numbers
Author(s) -
Mikl Martin,
Vendra Georgia,
Kiebler Michael A
Publication year - 2011
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2011.149
Subject(s) - ribonucleoprotein , microbiology and biotechnology , rna , biology , rna binding protein , messenger rna , actin , calmodulin , genetics , gene , biochemistry , enzyme
Messenger RNA localization involves the assembly of ribonucleoprotein particles (RNPs) and their subsequent transport along the cytoskeleton to their final destination. Here, we provide new evidence that microtubule‐associated protein 2 ( MAP2 ), calcium/calmodulin‐dependent protein kinase II ( CaMKIIα ) and β‐actin RNAs localize to dendrites in distinct RNPs, which contain—unexpectedly—very few RNA molecules. The number of MAP2 molecules per particle is affected by synaptic activity and Staufen 2, indicating that RNP composition is tightly controlled. Our data suggest that the independent localization of individual RNAs in low copy numbers could contribute to tighter temporal and spatial control of expression in neurons and synapse‐specific plasticity.