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Notch signalling is crucial for the correct development and growth of numerous organs and tissues, and when subverted it can cause cancer. Loss of miR‐8/200 microRNAs (miRNAs) is commonly observed in advanced tumours and correlates with their invasion and acquisition of stem‐like properties. Here, we show that this miRNA family controls Notch signalling activation in  Drosophila  and human cells. In an overexpression screen, we identified the  Drosophila  miR‐8 as a potent inhibitor of Notch‐induced overgrowth and tumour metastasis. Gain and loss of  mir‐8  provoked developmental defects reminiscent of impaired Notch signalling and we demonstrated that miR‐8 directly inhibits Notch ligand Serrate. Likewise, miR‐200c and miR‐141 directly inhibited JAGGED1, impeding proliferation of human metastatic prostate cancer cells. It has been suggested that JAGGED1 may also be important for metastases. Although in metastatic cancer cells, JAGGED1 modestly regulated  ZEB1 , the miR‐200c's target in invasion, studies in  Drosophila  revealed that only concurrent overexpression of  Notch  and  Zfh1 / ZEB1  induced tumour metastases. Together, these data define a new way to attenuate or boost Notch signalling that may have clinical interest.

Targeting Notch signalling by the conserved miR‐8/200 microRNA family in development and cancer cells