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A new function for an old organelle: microtubule nucleation at the Golgi apparatus
Author(s) -
Kodani Andrew,
Sütterlin Christine
Publication year - 2009
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2009.85
Subject(s) - biology , microtubule , centrosome , golgi apparatus , organelle , nobel laureate , microbiology and biotechnology , cell , cell cycle , genetics , endoplasmic reticulum , art , literature , poetry
The microtubule cytoskeleton of a mammalian cell originates from the perinuclear region and controls membrane trafficking, organelle positioning, and cell polarisation. Although the centrosome is viewed as the major microtubule organising centre, there is emerging evidence that the Golgi apparatus also has a role in the nucleation of perinuclear microtubules during the interphase. In a recent paper in The EMBO Journal, Rivero and colleagues reported the identification of a microtubule nucleation machinery at the Golgi and provided clues about functional differences between Golgi‐ and centrosome‐nucleated microtubules.