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A histone code for the DNA damage response in mammalian cells?
Author(s) -
Corpet Armelle,
Almouzni Geneviève
Publication year - 2009
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2009.180
Subject(s) - biology , dna damage , histone , dna , genetics , histone code , microbiology and biotechnology , computational biology , nucleosome
DNA repair in the context of chromatin represents a challenge both in terms of accessibility to the lesion and maintenance of genome stability. Histones, the main protein component of chromatin, can be subjected to a variety of post‐translational modifications (PTMs) that impact on genome function by either directly affecting nucleosome stability or providing a docking site for distinct regulatory proteins. In this issue of EMBO Journal , Tjeertes et al investigate histone PTMs with a specific involvement in the DNA damage response (DDR).