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One way for the gastric proton pump
Author(s) -
Nissen Poul
Publication year - 2009
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2009.137
Subject(s) - heartburn , nissen fundoplication , biology , nak , medicine , reflux , disease , engineering , telecommunications link , telecommunications
We are occasionally reminded of the gastric proton pump (H+,K+‐ATPase) acidifying the gastric juice as an unpleasant symptom of heartburn. A paper by Abe et al in this issue of the EMBO Journal ([Abe et al (2009)][1]) provides new structural insight into this important ion pump and drug target. Combining a docking model obtained from electron microscopy with mutational studies, the paper addresses the underlying mechanism of resistance of H+,K+‐ATPase to a million‐fold pH gradient. [1]: #ref-1