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Transient receptor potential channels meet phosphoinositides
Author(s) -
Nilius Bernd,
Owsianik Grzegorz,
Voets Thomas
Publication year - 2008
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2008.217
Subject(s) - biology , transient receptor potential channel , transient (computer programming) , receptor , neuroscience , microbiology and biotechnology , genetics , computer science , operating system
Transient receptor potential (TRP) cation channels are unique cellular sensors that are involved in multiple cellular functions, ranging from transduction of sensory signals to the regulation of Ca 2+ and Mg 2+ homoeostasis. Malfunctioning of TRP channels is now recognized as the cause of several hereditary and acquired human diseases. At the time of cloning of the first Drosophila TRP channel, a close connection between gating and phosphatidylinositol phosphates (PIPs) was already recognized. In this review, we summarize current knowledge about the mechanisms of interaction between TRP channels and PIPs, and discuss the possible functional implications of TRP—PIP interactions to human physiology and pathophysiology.