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Biogenesis of the Sorting Endosome: The Role of Rab5
Author(s) -
Woodman Philip G.
Publication year - 2000
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1034/j.1600-0854.2000.010902.x
Subject(s) - endosome , endocytic cycle , biogenesis , biology , microbiology and biotechnology , lipid bilayer fusion , function (biology) , protein targeting , endocytosis , escrt , membrane protein , membrane , biochemistry , receptor , gene , intracellular
Rab5 is a regulatory guanosine triphosphatase that is associated with the sorting endosome and participates in endosomal membrane fusion reactions. Recent experiments have provided insights into Rab5 function by demonstrating direct links between Rab5‐interacting proteins and components of the membrane fusion apparatus. In addition, a realisation that Rab5 has additional functions in endosome biogenesis is emerging. These advances may be profoundly important in changing the way that we view the sorting endosome and in developing models that properly reflect the dynamic qualities of the endocytic pathway.