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Immune responses in baboons vaccinated with HIV‐2 genetic expression libraries
Author(s) -
Locher C.P.,
Sykes K.F.,
Blackbourn D.J.,
Johnston S.A.
Publication year - 2002
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1034/j.1600-0684.2002.01035.x
Subject(s) - immunization , immune system , virology , biology , antibody , immunology , virus , epitope , cd8 , immunity , dna vaccination , t cell
Immunization using genetic expression libraries may be an improvement over conventional DNA immunization using a single gene because more epitopes are simultaneously presented to the immune system. In this study, we evaluated the effectiveness of an HIV‐2 vaccine made from a genomic expression library in baboons. We found that HIV‐2 expression library immunization induced HIV‐2‐specific memory responses but low levels of CD8+ cell anti‐viral responses and neutralizing antibodies. After intravenous virus challenge using a homologous pathogenic variant, HIV‐2 UC2/9429 , viral loads were similar in the HIV‐2‐immunized and control baboons. We conclude that although immunization using HIV‐2 expression libraries induces immune responses, this approach does not provide protection in baboons against intravenous challenge with HIV‐2.