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Acute megakaryocytic leukemia in essential thrombocythemia: an unusual evolution?
Author(s) -
Radaelli Franca,
Mazza Rita,
Curioni Elisabetta,
Ciani Alberto,
Pomati Mauro,
Maiolo AnnaTeresa
Publication year - 2002
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1034/j.1600-0609.2002.02734.x
Subject(s) - essential thrombocythemia , medicine , acute leukemia , immunophenotyping , acute myeloblastic leukemia , leukemia , acute megakaryoblastic leukemia , platelet , immunology , antigen
Essential thrombocythemia (ET) is a chronic myeloproliferative disorder that can rarely undergo leukemic transformation either in treated (3–7%) or untreated patients (1%). Evolution to myeloblastic or myelomonoblastic acute leukemia is commonly described in the literature, whereas lymphatic and megakaryocytic forms are considered unusual. Here, we report three cases of acute megakaryocytic leukemia (LMA‐M7) among 11 acute leukemic transformations observed in our series of 321 ET patients. LMA‐M7 was diagnosed employing immunophenotyping according to FAB criteria. These recurrences of LMA M7 suggest that this kind of evolution cannot be considered rare or casual in ET.