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HIP1 as a marker of aggressive prostate cancer
Author(s) -
Chan EYW
Publication year - 2002
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1034/j.1399-0004.2002.620503_4.x
Subject(s) - citation , medicine , family medicine , library science , computer science
A recent report from Theadora Ross’s group describes an exciting link between huntingtin interacting protein-1 (HIP1) and prostate cancer, providing further evidence for a critical role of this protein in the regulation of cell survival. HIP1 was initially identified by virtue of its interaction with huntingtin, the protein mutated in the neurodegenerative disorder Huntington disease (HD). The role of HIP1 in HD has been postulated to reflect a pro-apoptotic function in the cytoplasm (4,5)