HIP1 as a marker of aggressive prostate cancer

A recent report from Theadora Ross’s group describes an exciting link between huntingtin interacting protein-1 (HIP1) and prostate cancer, providing further evidence for a critical role of this protein in the regulation of cell survival. HIP1 was initially identified by virtue of its interaction with huntingtin, the protein mutated in the neurodegenerative disorder Huntington disease (HD). The role of HIP1 in HD has been postulated to reflect a pro-apoptotic function in the cytoplasm (4,5)