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Severe 5‐fluorouracil toxicity caused by reduced dihydropyrimidine dehydrogenase activity due to heterozygosity for a G→A point mutation
Author(s) -
Kuilenburg A. B. P.,
Vreken P.,
Beex L. V. A. M.,
De Abreu R. A.,
Gennip A. H.
Publication year - 1998
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1023/a:1005384609289
Subject(s) - point mutation , dihydropyrimidine dehydrogenase , citation , fluorouracil , mutation , loss of heterozygosity , genetics , toxicity , philosophy , medicine , library science , computer science , biology , gene , cancer , allele , thymidylate synthase
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