Premium
Evaluation of Oxygen Mass Transfer in Aspergillus niger Fermentation Using Data Reconciliation
Author(s) -
Patel Nilesh,
Thibault Jules
Publication year - 2008
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp0341545
Subject(s) - aspergillus niger , fermentation , chemistry , aspergillus , oxygen , food science , microbiology and biotechnology , biology , organic chemistry
Abstract Fermentation experiments using Aspergillus niger result in a very viscous broth due to the growth of filamentous microorganism. For viscous fermentation processes, it is difficult to estimate with confidence the volumetric oxygen mass transfer coefficient ( K L a ), which can be used for scale‐up or design of bioreactors. In the present study, four methods based on dynamic and stationary approaches were used to measure K L a throughout the fermentation. Data reconciliation was used to obtain a more reliable and consistent K L a . The K L a value obtained by a data reconciliation technique was found to be more reliable since it takes into consideration both the reliability of all measured variables and the accuracy of all mass balance equations.