Open AccessFunctionalized Boron Nanoparticles as Potential Promising Antimalarial Agents
Author(s) -
Yinghuai Zhu,
Parichat Prommana,
Narayan S. Hosmane,
Paolo Coghi,
Chairat Uthaipibull,
Yingjun Zhang
Publication year - 2022
Publication title -
acs omega
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.1c05888
Subject(s) - chemistry , fourier transform infrared spectroscopy , nuclear chemistry , dynamic light scattering , nanoparticle , x ray photoelectron spectroscopy , transmission electron microscopy , materials science , nuclear magnetic resonance , nanotechnology , chemical engineering , physics , engineering
Boron nanoparticles (BNPs), functionalized with hydroxyl groups, were synthesized in situ by a cascade process, followed by bromination and hydrolyzation reactions. These functionalized BNPs, (B m (OH) n ), were characterized using 1 H and 11 B NMR spectra, Fourier-transform infrared (FT-IR) spectroscopy, inductively coupled plasma-optical emission spectroscopy (ICP-OES), transmission electron microscopy (TEM), dynamic light scattering (DLS), and X-ray photoelectron spectroscopy (XPS) methods. These nanoparticles were also evaluated in vitro for their antimalarial activity against Plasmodium falciparum (3D7 strain) with an IC 50 value of 0.0021 μM and showed low toxicity to Uppsala 87 malignant glioma (U87MG) cell lines, malignant melanoma A375 cell lines, KB human oral cancer cell lines, rat cortical neuron cell lines, and rat fibroblast-like synoviocyte (FLS) cell lines.