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Levonadifloxacin (WCK 771) is a novel broad-spectrum anti-methicillin-resistan Staphylococcus aureus (MRSA) agent recently launched in India. Five process impurities and one degradation impurity were synthesized as reference standards for their quantification by high-performance liquid chromatography (HPLC) methodology in drug substance and drug product. These compounds are not easily commercially available. The synthesis and characterization of these impurities are discussed in detail.

Efficient Synthesis of Potential Impurities in Levonadifloxacin (WCK 771)