Open AccessCatalyst-Free Visible-Light-Promoted Cyclization of Aldehydes: Access to 2,5-Disubstituted 1,3,4-Oxadiazole Derivatives
Author(s) -
Jian Li,
Jin-Xia Wen,
Xue-Chen Lu,
Guo-Quan Hou,
Xu Gao,
Yang Li,
Li Liu
Publication year - 2021
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.1c04098
Subject(s) - hypervalent molecule , reagent , catalysis , chemistry , iodine , combinatorial chemistry , photoredox catalysis , oxadiazole , visible spectrum , aldehyde , reaction conditions , organic chemistry , photochemistry , photocatalysis , materials science , optoelectronics
An efficient synthesis of a variety of 2,5-disubstituted 1,3,4-oxadiazole derivatives via a cyclization reaction by photoredox catalysis between aldehydes and hypervalent iodine(III) reagents is described. The reaction proceeds under mild conditions and affords various target compounds in excellent yields. The commercially available aldehydes without preactivation and a simple visible-light-promoted procedure without any catalysts make this strategy an alternative to the conventional methods.