Open AccessCopper-Promoted Conjugate Addition of Carboxylic Acids to Ethenesulfonyl Fluoride (ESF) for Constructing Aliphatic Sulfonyl Fluorides
Author(s) -
Xu Zhang,
Yumei Huang,
HuaLi Qin,
Baoguo Zhang,
K.P. Rakesh,
Haolin Tang
Publication year - 2021
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.1c02804
Subject(s) - sulfonyl , chemistry , moiety , fluoride , conjugate , carboxylic acid , nucleophile , organic chemistry , aspirin , molecule , copper , medicinal chemistry , catalysis , inorganic chemistry , mathematical analysis , biochemistry , alkyl , mathematics
A CuO-promoted direct hydrocarboxylation of ethenesulfonyl fluoride (ESF) was developed using carboxylic acid as a nucleophile under mild conditions. A variety of molecules containing both ester group and aliphatic sulfonyl fluoride moiety exhibit great potential in medicinal chemistry and chemical biology. Furthermore, the modification of the known drugs Ibuprofen and Aspirin was also demonstrated.