Open AccessCytotoxicity and Cellular Death Modality of Surface-Decorated Gold Nanorods against a Panel of Breast Cancer Cell Lines
Author(s) -
Rana AbuDahab,
Nouf N. Mahmoud,
Maha Abdallah,
Lama Hamadneh,
Suhair Hikmat,
Rand Zaza,
Duaa Abuarqoub,
Enam A. Khalil
Publication year - 2021
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.1c01386
Subject(s) - cytotoxicity , apoptosis , programmed cell death , cell culture , cdh1 , cancer research , cell , cell adhesion , microbiology and biotechnology , cancer cell , nanorod , cell growth , metastasis , chemistry , cancer , biology , nanotechnology , in vitro , medicine , materials science , cadherin , biochemistry , genetics
Herein, the antiproliferative effect of surface-decorated gold nanorods (GNRs) was investigated against three different breast cancer cell lines. The results indicate that the cell lines exhibited different biological responses and death modalities toward the treatment. The cell lines exhibited similar cellular uptake of the nanoparticles; however, MDA-MB-231 demonstrated the highest cytotoxicity compared to other cell lines upon treatment with GNRs. The expression of the CDH1 gene, which is involved in cell adhesion and metastasis, was dramatically increased in treated MDA-MB-231 cells compared to other cell lines. Early apoptosis and late apoptosis are the dominant cellular death modalities of MDA-MB-231 cells upon treatment with GNRs.