Open AccessSynthesis of 1H-Indazoles via Silver(I)-Mediated Intramolecular Oxidative C–H Bond Amination
Author(s) -
Areum Park,
Kyu Sung Jeong,
Hyuk Lee,
Hyunwoo Kim
Publication year - 2021
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.1c00025
Subject(s) - amination , intramolecular force , oxidative phosphorylation , chemistry , electron transfer , combinatorial chemistry , radical , medicinal chemistry , stereochemistry , organic chemistry , catalysis , biochemistry
We described a silver(I)-mediated intramolecular oxidative C-H amination that enables the construction of assorted 1 H -indazoles that are widely applicable in medicinal chemistry. The developed amination was found to be efficient for the synthesis of a variety of 3-substituted indazoles that are otherwise difficult to be synthesized by other means of C-H aminations. Preliminary mechanistic studies suggested that the current amination proceeds via single electron transfer (SET) mediated by Ag(I) oxidant.